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Biomimetic NanoForumlation For Targeted Osteosarcoma Therapy (Available for Licensing in Any Country)
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Sector: MEDICAL, Origin: INDIA
Osteosarcoma is a fast-growing malignant bone tumor with early metastasis, requiring early diagnosis and precise treatment. Conventional therapies often fail due to drug resistance and poor targeting, risking damage to healthy tissues
This invention presents a biomimetic nanoformulation using PLGA nanoparticles coated with K7M2 osteosarcoma cell membranes.
These Cell Membrane-Coated Nanoparticles (CMCNPs) deliver siRNA against the Survivin gene, achieving tumour-specific uptake via homotypic recognition.
Key Highlights:
- The use of K7M2 osteosarcoma cell membranes enables precise self-recognition by tumor cells and improves targeting specificity.
- By restricting siRNA delivery primarily to osteosarcoma cells, it significantly reduces off-target cytotoxicity, offering a safer alternative to traditional chemotherapy
- Built-in fluorescent tagging approach allows real-time monitoring
- Built on FDA-approved PLGA nanoparticles, supporting safety and translational potential
Patent:
Indian Patent Filed ( 202531048304 )
Development Stage:
TRL – 4
Seeking:
Available for Licensing or for Collaboration in any BRICS+. Country
- Expansion to International market through collaboration with Government/Private hospitals
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